Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 2/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760082 | 0.89 | NOTUM (0.38) | LMNAMAPTSMN1; SMN2TP53THRB | |
| SCHEMBL22760364 | 0.89 | FOLH1 (0.37) | EDNRAFOLH1LMNATSHRMAPT | |
| SCHEMBL22760117 | 0.88 | FOLH1 (0.36) | EDNRAFOLH1LMNATSHRMAPK8 | |
| SCHEMBL22760095 | 0.88 | MAPT (0.48) | MAPTSMN1; SMN2TP53THRBALDH1A1 | |
| SCHEMBL22760062 | 0.87 | EDNRA (0.39) | EDNRAFOLH1LMNAMAPK8ALDH1A1 | |
| SCHEMBL22747865 | 0.86 | FOLH1 (0.35) | EDNRAFOLH1LMNATSHRMAPK8 | |
| SCHEMBL22747868 | 0.86 | FOLH1 (0.35) | EDNRAFOLH1LMNATSHRMAPK8 | |
| SCHEMBL22747829 | 0.86 | FOLH1 (0.35) | EDNRAFOLH1LMNATSHRMAPK8 | |
| SCHEMBL22760068 | 0.84 | CENPE (0.38) | LMNATSHRMAPK8MAPTSMN1; SMN2 | |
| SCHEMBL22760158 | 0.83 | NOTUM (0.41) | EDNRALMNATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |