Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAT2A | P31153 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760364 | 0.89 | FOLH1 (0.37) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22748351 | 0.88 | MAPT (0.48) | LMNAALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL22760085 | 0.86 | EDNRA (0.37) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22760070 | 0.86 | FOLH1 (0.35) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22747832 | 0.84 | FOLH1 (0.40) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22760196 | 0.82 | FOLH1 (0.38) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22747858 | 0.82 | FOLH1 (0.40) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22747868 | 0.81 | FOLH1 (0.35) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22747829 | 0.81 | FOLH1 (0.35) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22760158 | 0.81 | NOTUM (0.41) | LMNATSHRALDH1A1EDNRAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |