Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.38 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | BHMT | Q93088 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL460293 | 0.83 | LMNA (0.67) | TSHRLMNAHSD17B10KMT2ATDP1 | |
| SCHEMBL1014295 | 0.81 | TSHR (0.30) | TSHR | |
| SCHEMBL95982 | 0.81 | TSHR (1.00) | TSHRLMNAHSD17B10KMT2ATDP1 | |
| SCHEMBL10107013 | 0.78 | TSHR (0.62) | TSHRLMNAHSD17B10KMT2ATDP1 | |
| Hydrochloric Acid SCHEMBL10457214 | 0.78 | TSHR (0.93) | TSHRLMNAHSD17B10KMT2ATDP1 | |
| SCHEMBL30845449 | 0.78 | TSHR (0.93) | TSHRLMNAHSD17B10KMT2ATDP1 | |
| Ammonia Solution, Strong SCHEMBL8958644 | 0.78 | TSHR (0.93) | TSHRLMNAHSD17B10KMT2ATDP1 | |
| Selenium SCHEMBL30845448 | 0.78 | TSHR (0.93) | TSHRLMNAHSD17B10KMT2ATDP1 | |
| Water SCHEMBL11221867 | 0.78 | TSHR (0.93) | TSHRLMNAHSD17B10KMT2ATDP1 | |
| Hydrogen Sulfide SCHEMBL28318293 | 0.78 | TSHR (0.93) | TSHRLMNAHSD17B10KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994280-B2 | disulfide bond formation in solid phase peptide synthesis; starting with a cysteine that is protected in its side chain by a S-tert-butyl-sulphenyl group and which is N-terminally substituted at its N.alpha. and 3,3'-dithio-propionimide; coupling, cyclization; Eptifibatide on Sieber resin | LONZA AG (CH) | 2011-08-09 | — | — | US | claimed |
| EP-1805203-B1 | ON-RESIN PEPTIDE CYCLIZATION | LONZA AG (CH) | 2010-01-13 | — | — | EP | claimed |