Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 7/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2278540 | 0.93 | PRKCA (0.43) | PRKCAMMP12NR1I2CYP3A4CYP2C19 | |
| SCHEMBL2276924 | 0.86 | NR1I2 (0.42) | PRKCAMMP12NR1I2CYP3A4CYP2C19 | |
| SCHEMBL395378 | 0.83 | PRKCA (0.50) | PRKCAMMP12NR1I2CYP3A4CYP2C19 | |
| SCHEMBL393139 | 0.80 | PRKCA (0.39) | PRKCAMMP12NR1I2CYP3A4CYP2C19 | |
| SCHEMBL2277958 | 0.80 | PRKCA (0.46) | PRKCAMMP12NR1I2CYP3A4CYP2C19 | |
| SCHEMBL4206520 | 0.79 | PRKCA (0.61) | PRKCAMMP12NR1I2CYP3A4CYP2C19 | |
| SCHEMBL4213725 | 0.78 | NR1I2 (0.44) | PRKCAMMP12NR1I2CYP3A4CYP2C19 | |
| SCHEMBL394249 | 0.78 | PRKCA (0.49) | PRKCAMMP12NR1I2CYP3A4CYP2C19 | |
| SCHEMBL395445 | 0.77 | PRKCA (0.42) | PRKCAMMP12NR1I2CYP3A4CYP2C19 | |
| SCHEMBL12427939 | 0.77 | PRKCA (0.49) | PRKCAMMP12NR1I2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |
| US-20090048239-A1 | Therapeutic compounds | MSD ITALIA S.R.L. (IT) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048239-A1 | Therapeutic compounds | RRP1B, RCE1, CTSZ | PRKCA 4250/4885MMP12 2067/4885NR1I2 381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.