Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28170196 | 0.75 | GLA (0.50) | GLAKMT2A | |
| SCHEMBL22750775 | 0.70 | — | — | |
| SCHEMBL28320299 | 0.67 | — | — | |
| SCHEMBL12356624 | 0.67 | — | — | |
| SCHEMBL6432606 | 0.65 | — | — | |
| SCHEMBL19820390 | 0.62 | GLA (0.39) | GLA | |
| SCHEMBL7785889 | 0.62 | — | — | |
| SCHEMBL844148 | 0.61 | LMNA (0.53) | KMT2A | |
| SCHEMBL16509771 | 0.60 | GLA (0.36) | GLA | |
| SCHEMBL26011809 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240276957-A1 | METHODS OF TREATMENT WITH AMINOLEVULINIC ACID SYNTHASE 2 (ALAS2) MODULATORS | AGIOS PHARMACEUTICALS, INC. | 2024-08-22 | — | — | US | disclosed |
| CN-114174288-A | Methods of treatment with aminolevulinic acid synthase 2(ALAS2) modulators | 安吉奥斯医药品有限公司 | 2022-03-11 | — | — | CN | disclosed |
| WO-2020247819-A2 | METHODS OF TREATMENT WITH AMINOLEVULINIC ACID SYNTHASE 2 (ALAS2) MODULATORS | AGIOS PHARMACEUTICALS, INC. (US) | 2020-12-10 | — | — | WO | disclosed |
| WO-2020247819-A2 | METHODS OF TREATMENT WITH AMINOLEVULINIC ACID SYNTHASE 2 (ALAS2) MODULATORS | AGIOS PHARMACEUTICALS, INC. (US) | 2020-12-10 | — | — | WO | disclosed |