Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.56 |
| ▸ | MMP12 | P39900 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 7/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2279113 | 0.94 | PRKCA (0.54) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL4208637 | 0.93 | PRKCA (0.65) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2277012 | 0.91 | PRKCA (0.56) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2276695 | 0.90 | PRKCA (0.55) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2277987 | 0.90 | PRKCA (0.52) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL4208309 | 0.88 | PRKCA (0.62) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2277965 | 0.87 | PRKCA (0.54) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2278834 | 0.86 | PRKCA (0.55) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2275104 | 0.84 | PRKCA (0.53) | PRKCAMMP12NR1I2 | |
| SCHEMBL4212003 | 0.84 | PRKCA (0.65) | PRKCAMMP12NR1I2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |