Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.42 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17149668 | 0.76 | NPC1 (0.67) | NPC1LMNACYP1A2CYP3A4HPGD | |
| SCHEMBL18766888 | 0.72 | ALDH1A1 (0.45) | LMNACYP3A4HTTTRPV1 | |
| SCHEMBL21920987 | 0.67 | KDM4E (0.51) | LMNAHPGDCYP2C19FLT3 | |
| SCHEMBL21600866 | 0.66 | JAK2 (0.58) | NPC1LMNACYP1A2CYP3A4HPGD | |
| SCHEMBL16703680 | 0.64 | JAK2 (0.58) | NPC1LMNACYP1A2CYP3A4HPGD | |
| SCHEMBL18193501 | 0.64 | JAK2 (0.58) | NPC1LMNACYP1A2CYP3A4HPGD | |
| SCHEMBL8536021 | 0.64 | KDM4E (0.47) | LMNACYP1A2HPGDCYP2C19FLT3 | |
| SCHEMBL29958279 | 0.63 | JAK2 (0.54) | NPC1LMNACYP1A2CYP3A4HPGD | |
| SCHEMBL24196560 | 0.63 | IDO1 (0.49) | LMNAHPGDCYP2C19FLT3 | |
| SCHEMBL30270464 | 0.63 | IDO1 (0.49) | LMNAHPGDCYP2C19FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10858319-B2 | Indole derivatives for use in medicine | IOMET PHARMA LTD. (GB) | 2020-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10858319-B2 | Indole derivatives for use in medicine | IDO1, IDO2, TDO2 | NPC1 3828/4885LMNA 4104/4885CYP1A2 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.