Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 6/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 4/20 | 0.38 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15296871 | 0.90 | HDAC3 (0.43) | HDAC3SYKHDAC6PDPK1KDR | |
| SCHEMBL16520986 | 0.86 | SYK (0.45) | HDAC3SYKPDPK1KDRNPC1 | |
| SCHEMBL22754355 | 0.86 | HDAC3 (0.40) | HDAC3SYKHDAC6PDPK1KDR | |
| SCHEMBL21171369 | 0.86 | MET (0.47) | HDAC3SYKHDAC6PDPK1KDR | |
| SCHEMBL15296664 | 0.83 | MET (0.46) | HDAC3SYKPDPK1KDRMET | |
| SCHEMBL19961116 | 0.83 | SYK (0.46) | HDAC3SYKPDPK1KDRNPC1 | |
| SCHEMBL22754437 | 0.82 | JAK3 (0.38) | KDRNPC1 | |
| SCHEMBL22754338 | 0.82 | SYK (0.43) | HDAC3SYKPDPK1KDRHDAC4 | |
| SCHEMBL21171384 | 0.82 | HDAC3 (0.42) | HDAC3SYKHDAC6PDPK1KDR | |
| SCHEMBL21171388 | 0.81 | MET (0.49) | PDPK1METCDKL5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2831073-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN KINASES | RHIZEN PHARMACEUTICALS S A (CH) | 2020-12-09 | — | — | EP | disclosed |