Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.51 |
| ▸ | RAB9A | P51151 | 11/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.51 |
| ▸ | TP53 | P04637 | 4/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29839305 | 0.77 | KMT2A (0.54) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL22729649 | 0.77 | KMT2A (0.54) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL22729398 | 0.75 | UGCG (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL29839386 | 0.75 | UGCG (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL18132519 | 0.71 | RAB9A (0.76) | NPC1RAB9ASMN1; SMN2TP53HIF1A | |
| SCHEMBL22729507 | 0.70 | PDE10A (0.49) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL22729668 | 0.70 | PDE10A (0.47) | NPC1RAB9ATP53ALDH1A1MAPT | |
| SCHEMBL31713030 | 0.69 | RAB9A (0.76) | NPC1RAB9ASMN1; SMN2TP53HIF1A | |
| SCHEMBL22729597 | 0.68 | PDE10A (0.49) | NPC1RAB9ATP53ALDH1A1MAPT | |
| SCHEMBL7221113 | 0.66 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2TP53HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3747885-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2020-12-09 | — | — | EP | disclosed |