SCHEMBL22756342

SCHEMBL22756342

CCCN1C(=O)CCc2cc(N[S+]([O-])Cc3ccc(Cl)cc3F)ccc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDH1 O75874 1/20 0.38
HDAC1 Q13547 4/20 0.38
HDAC6 Q9UBN7 4/20 0.38
HDAC8 Q9BY41 3/20 0.38
ATAD2 Q6PL18 1/20 0.35
CHRM1 P11229 3/20 0.34
CES2 O00748 1/20 0.34
DRD3 P35462 4/20 0.33
DRD2 P14416 3/20 0.33
DRD4 P21917 3/20 0.33
HTR1A P08908 1/20 0.33
OPRK1 P41145 1/20 0.33
HTR3A P46098 1/20 0.33
KCNH2 Q12809 1/20 0.33
GHSR Q92847 1/20 0.33
MET P08581 1/20 0.33
LMNA P02545 1/20 0.33
POLB P06746 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
NPY5R Q15761 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20344775 0.90 GRIN1 (0.37) HDAC1HDAC6HDAC8ATAD2CHRM1
SCHEMBL20344693 0.82 HDAC6 (0.38) HDAC1HDAC6HDAC8ATAD2CHRM1
SCHEMBL22692407 0.81 IDH1 (0.43) IDH1HDAC1HDAC6HDAC8ATAD2
SCHEMBL20344815 0.81 HDAC1 (0.41) IDH1HDAC1HDAC6HDAC8ATAD2
SCHEMBL20344756 0.80 HDAC1 (0.37) HDAC1HDAC6HDAC8ATAD2CHRM1
SCHEMBL22756341 0.80 ATAD2 (0.37) IDH1HDAC1HDAC6HDAC8ATAD2
SCHEMBL20344778 0.79 HDAC1 (0.39) IDH1HDAC1HDAC6HDAC8ATAD2
SCHEMBL20344782 0.78 HDAC6 (0.35) HDAC1HDAC6HDAC8ATAD2CHRM1
SCHEMBL20344812 0.78 ATAD2 (0.35) HDAC1HDAC6HDAC8ATAD2CHRM1
SCHEMBL20344703 0.72 IDH1 (0.42) IDH1HDAC1HDAC6HDAC8ATAD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3342766-B1 SMALL MOLECULE COMPOUND FOR ENHANCING PLANT STRESS RESISTANCE CAS CENTER FOR EXCELLENCE IN MOLECULAR PLANT SCIENCES (CN) 2020-12-09 EP disclosed