Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.50 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.38 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.38 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22759089 | 1.00 | MTOR (0.50) | MTORATRPIK3CDPIK3R1PIK3CA | |
| SCHEMBL4974288 | 0.80 | FPR2 (0.37) | MTORPIK3R1PIK3CA | |
| SCHEMBL4974284 | 0.80 | FPR2 (0.37) | MTORPIK3R1PIK3CA | |
| SCHEMBL24069658 | 0.79 | MTOR (0.44) | MTORATRPIK3CDPIK3R1PIK3CA | |
| SCHEMBL3399370 | 0.78 | MTOR (0.44) | MTORATRPIK3C3 | |
| SCHEMBL3399374 | 0.78 | MTOR (0.44) | MTORATRPIK3C3 | |
| SCHEMBL2708210 | 0.77 | MTOR (0.47) | MTORPIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL2708205 | 0.77 | MTOR (0.47) | MTORPIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL2908876 | 0.76 | MTOR (0.41) | MTOR | |
| SCHEMBL20692837 | 0.75 | MTOR (0.53) | MTORPIK3R1PIK3CARICTORRPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244613-A1 | 2, 4, 6-TRI-SUBSTITUTED PYRIMIDINE COMPOUND AS ATR KINASE INHIBITOR | 北京泰德制药股份有限公司 | 2020-12-10 | — | — | WO | disclosed |