Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | MTOR | P42345 | 5/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | TYK2 | P29597 | 4/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4974284 | 1.00 | FPR2 (0.37) | FPR2SCN9APIK3R1PIK3CAMTOR | |
| SCHEMBL9937466 | 0.85 | PDK1 (0.35) | FPR2SCN9APIK3R1PIK3CAMTOR | |
| SCHEMBL9937328 | 0.81 | SMN1; SMN2 (0.37) | FPR2SCN9APIK3R1PIK3CAMTOR | |
| SCHEMBL22759089 | 0.80 | MTOR (0.50) | PIK3R1PIK3CAMTOR | |
| SCHEMBL22759261 | 0.80 | MTOR (0.50) | PIK3R1PIK3CAMTOR | |
| SCHEMBL4974339 | 0.79 | MTOR (0.34) | MTOR | |
| SCHEMBL4974343 | 0.79 | MTOR (0.34) | MTOR | |
| SCHEMBL17465731 | 0.78 | IRAK4 (0.37) | FPR2SCN9APIK3R1PIK3CAMTOR | |
| SCHEMBL16914042 | 0.76 | PIK3CA (0.40) | FPR2SCN9APIK3R1PIK3CAMTOR | |
| SCHEMBL16914276 | 0.76 | PIK3CA (0.40) | FPR2SCN9APIK3R1PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |