Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 12/20 | 0.50 |
| ▸ | RAB9A | P51151 | 12/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22761301 | 0.83 | NOTUM (0.63) | SMN1; SMN2NPC1RAB9ACYP1A2CYP2C19 | |
| SCHEMBL2768635 | 0.80 | NOTUM (0.70) | SMN1; SMN2NPC1RAB9ANPSR1CYP1A2 | |
| SCHEMBL22761276 | 0.80 | NPC1 (0.47) | SMN1; SMN2NPC1RAB9AMAPTNOTUM | |
| SCHEMBL22761436 | 0.80 | LMNA (0.54) | SMN1; SMN2MAPTLMNAS1PR1 | |
| SCHEMBL22761300 | 0.80 | CHRNB2 (0.63) | SMN1; SMN2NPC1RAB9ANPSR1MAPT | |
| SCHEMBL22761279 | 0.76 | NPC1 (0.56) | SMN1; SMN2NPC1RAB9ANPSR1MAPT | |
| SCHEMBL5959967 | 0.74 | SMN1; SMN2 (0.85) | SMN1; SMN2NPC1RAB9ANPSR1MAPT | |
| SCHEMBL22761433 | 0.73 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9ANPSR1CYP1A2 | |
| SCHEMBL11038681 | 0.71 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ANPSR1CYP1A2 | |
| SCHEMBL15088383 | 0.71 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ANPSR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020247819-A2 | METHODS OF TREATMENT WITH AMINOLEVULINIC ACID SYNTHASE 2 (ALAS2) MODULATORS | AGIOS PHARMACEUTICALS, INC. (US) | 2020-12-10 | — | — | WO | disclosed |