Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PPIA | P62937 | 1/20 | 0.34 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PPM1D | O15297 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4206515 | 0.93 | PRKCA (0.52) | PRKCAMMP12HDAC1HDAC8HDAC6 | |
| SCHEMBL2279215 | 0.91 | PRKCA (0.46) | PRKCAMMP12HDAC1HDAC8HDAC6 | |
| SCHEMBL2275315 | 0.89 | PRKCA (0.45) | PRKCAMMP12NR1I2CYP3A4ALDH1A1 | |
| SCHEMBL771223 | 0.88 | PRKCA (0.43) | PRKCAMMP12HDAC1HDAC8HDAC6 | |
| SCHEMBL2274258 | 0.88 | PRKCA (0.43) | PRKCAMMP12HDAC1HDAC8HDAC6 | |
| SCHEMBL4219730 | 0.86 | PRKCA (0.52) | PRKCAMMP12HDAC1HDAC8HDAC6 | |
| SCHEMBL4221755 | 0.84 | PRKCA (0.53) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL395908 | 0.83 | PRKCA (0.59) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2280934 | 0.83 | PRKCA (0.51) | PRKCAMMP12HDAC1HDAC8HDAC6 | |
| SCHEMBL3814277 | 0.83 | PRKCA (0.48) | PRKCAMMP12HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |