Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.51 |
| ▸ | MMP12 | P39900 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.31 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4213697 | 0.95 | PRKCA (0.57) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2276844 | 0.92 | PRKCA (0.52) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2278541 | 0.89 | PRKCA (0.47) | PRKCAMMP12NR1I2CNR2SMN1; SMN2 | |
| SCHEMBL2277222 | 0.88 | PRKCA (0.59) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2274258 | 0.88 | PRKCA (0.43) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2280938 | 0.87 | PRKCA (0.53) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL394842 | 0.87 | PRKCA (0.65) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2278084 | 0.85 | PRKCA (0.49) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2278012 | 0.85 | PRKCA (0.54) | PRKCAMMP12NR1I2CNR2TP53 | |
| SCHEMBL3684086 | 0.84 | PRKCA (0.60) | PRKCAMMP12NR1I2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |