Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 9/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2274247 | 0.95 | PRKCA (0.45) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2277220 | 0.87 | PRKCA (0.49) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2276489 | 0.86 | PRKCA (0.40) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2271808 | 0.85 | PRKCA (0.45) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2273287 | 0.85 | PRKCA (0.57) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2276880 | 0.84 | PRKCA (0.49) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2280077 | 0.83 | PRKCA (0.42) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2278806 | 0.81 | PRKCA (0.56) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2276844 | 0.81 | PRKCA (0.52) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2273152 | 0.81 | PRKCA (0.44) | PRKCAMMP12NR1I2KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |