Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 7/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CASR | P41180 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4211804 | 0.94 | PRKCA (0.48) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2274498 | 0.90 | PRKCA (0.53) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2274493 | 0.90 | PRKCA (0.53) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2274891 | 0.83 | PRKCA (0.44) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2273152 | 0.83 | PRKCA (0.44) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2271808 | 0.83 | PRKCA (0.45) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2276487 | 0.83 | PRKCA (0.40) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2274157 | 0.82 | PRKCA (0.44) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2276844 | 0.81 | PRKCA (0.52) | PRKCAMMP12NR1I2KCNH2CYP3A4 | |
| SCHEMBL2276303 | 0.80 | PRKCA (0.53) | PRKCAMMP12NR1I2KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |