Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 5/20 | 0.40 |
| ▸ | ACHE | P22303 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276561 | 1.00 | JAK2 (0.44) | JAK2JAK1HTR6ACHEPOLB | |
| SCHEMBL2278047 | 0.86 | JAK2 (0.44) | JAK2JAK1HTR6POLBSMN1; SMN2 | |
| SCHEMBL2277746 | 0.86 | JAK1 (0.45) | JAK2JAK1HTR6POLBSMN1; SMN2 | |
| SCHEMBL2279733 | 0.86 | JAK1 (0.60) | JAK2JAK1HTR6POLBSMN1; SMN2 | |
| SCHEMBL2224293 | 0.85 | JAK1 (0.46) | JAK2JAK1HTR6POLBHTR2A | |
| SCHEMBL2277491 | 0.85 | JAK2 (0.46) | JAK2JAK1HTR6POLBSMN1; SMN2 | |
| SCHEMBL2280024 | 0.84 | JAK1 (0.46) | JAK2JAK1HTR6SMN1; SMN2TYK2 | |
| SCHEMBL2274893 | 0.84 | JAK1 (0.45) | JAK2JAK1HTR6ACHEPOLB | |
| SCHEMBL2276629 | 0.84 | JAK1 (0.45) | JAK2JAK1HTR6POLBHTR2A | |
| SCHEMBL9952493 | 0.83 | HTR6 (0.43) | JAK2JAK1HTR6POLBHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |