Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 2/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22655752 | 0.88 | MAOB (0.49) | P2RX7MKNK1CDC7AXLMAOB | |
| SCHEMBL30177058 | 0.88 | MAOB (0.49) | P2RX7MKNK1CDC7AXLMAOB | |
| SCHEMBL22768570 | 0.84 | AXL (0.51) | MKNK1GRM4AXLIDO1TDO2 | |
| SCHEMBL21856670 | 0.83 | CDC7 (0.53) | MKNK1ALDH1A1CDC7AXL | |
| SCHEMBL30176980 | 0.83 | CDC7 (0.53) | MKNK1ALDH1A1CDC7AXL | |
| SCHEMBL30936711 | 0.79 | TGFBR1 (0.38) | P2RX7TGFBR1GRM4ALDH1A1MAPT | |
| SCHEMBL27216850 | 0.79 | TGFBR1 (0.38) | P2RX7TGFBR1GRM4ALDH1A1MAPT | |
| SCHEMBL29535923 | 0.78 | GRM4 (0.39) | P2RX7TGFBR1L3MBTL1GRM4ALDH1A1 | |
| SCHEMBL21901151 | 0.78 | GRM4 (0.39) | P2RX7TGFBR1L3MBTL1GRM4ALDH1A1 | |
| SCHEMBL21856798 | 0.78 | CDC7 (0.53) | MKNK1ALDH1A1CDC7AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020247160-A1 | CONDENSED TRYCICLIC PYRROLES AS ALPHA-1 ANTITRYPSIN MODULATORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-12-10 | — | — | WO | disclosed |