Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | AGPAT2 | O15120 | 3/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22655752 | 0.85 | MAOB (0.49) | AXLMKNK1KDRMAOB | |
| SCHEMBL30177058 | 0.85 | MAOB (0.49) | AXLMKNK1KDRMAOB | |
| SCHEMBL22768248 | 0.84 | P2RX7 (0.41) | AXLMKNK1GRM4IDO1TDO2 | |
| SCHEMBL23887998 | 0.81 | IDO1 (0.43) | AXLMKNK1GRM4IGF1RRET | |
| SCHEMBL30176991 | 0.81 | IDO1 (0.43) | AXLMKNK1GRM4IGF1RRET | |
| SCHEMBL21856670 | 0.80 | CDC7 (0.53) | AXLMKNK1KDR | |
| SCHEMBL30176980 | 0.80 | CDC7 (0.53) | AXLMKNK1KDR | |
| SCHEMBL30176948 | 0.79 | IDO1 (0.45) | GRM4IGF1RRETKDRIDO1 | |
| SCHEMBL23888101 | 0.79 | IDO1 (0.45) | GRM4IGF1RRETKDRIDO1 | |
| SCHEMBL23884038 | 0.76 | IDO1 (0.45) | GRM4IDO1TDO2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020247160-A1 | CONDENSED TRYCICLIC PYRROLES AS ALPHA-1 ANTITRYPSIN MODULATORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-12-10 | — | — | WO | disclosed |