Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | IGF2R | P11717 | 2/20 | 0.36 |
| ▸ | TK1 | P04183 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10216220 | 1.00 | CHRM5 (0.38) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL16157294 | 0.84 | CHRM5 (0.39) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL22769140 | 0.84 | CHRM5 (0.39) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL14704213 | 0.79 | TK1 (0.43) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL18352197 | 0.79 | GBA1 (0.41) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL16084863 | 0.78 | IGF2R (0.36) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL18352198 | 0.78 | GBA1 (0.43) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL19669024 | 0.78 | GBA1 (0.43) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL30163822 | 0.78 | IGF2R (0.36) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL17531586 | 0.78 | IGF2R (0.36) | CHRM5CHRM1CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091441-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES COMPRISING A TETRA-VALENT SUGAR CLUSTER FOR TREATMENT OF DIABETES | MERCK SHARP & DOHME LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2020247297-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2020-12-10 | — | — | WO | disclosed |