Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.34 |
| ▸ | CDK2 | P24941 | 4/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2277448 | 0.93 | PDPK1 (0.37) | PDPK1BRD4WNT1GSK3BDYRK1A | |
| SCHEMBL2750991 | 0.81 | PDPK1 (0.39) | PDPK1BRD4WNT1GSK3BDYRK1A | |
| SCHEMBL2277123 | 0.77 | TYRO3 (0.39) | PDPK1BRD4WNT1GSK3BDYRK1A | |
| SCHEMBL2754328 | 0.75 | PDPK1 (0.41) | PDPK1BRD4WNT1GSK3BDYRK1A | |
| SCHEMBL2277128 | 0.74 | MAPK1 (0.43) | PDPK1BRD4WNT1GSK3BDYRK1A | |
| SCHEMBL2277438 | 0.74 | PDPK1 (0.38) | PDPK1BRD4WNT1GSK3BDYRK1A | |
| SCHEMBL2283400 | 0.72 | PDPK1 (0.42) | PDPK1BRD4WNT1GSK3BDYRK1A | |
| SCHEMBL2752577 | 0.71 | PDPK1 (0.38) | PDPK1BRD4WNT1GSK3BDYRK1A | |
| SCHEMBL2750996 | 0.70 | PTGDR2 (0.38) | PDPK1WNT1GSK3BDYRK1ACCNA2 | |
| SCHEMBL2280859 | 0.70 | CDK2 (0.35) | PDPK1WNT1GSK3BDYRK1ACCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110195951-A1 | DIAZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195951-A1 | DIAZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | DAPK1, DAPK2, DAPK3 | PDPK1 115/4885BRD4 837/4885WNT1 2535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.