Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | ACVR2A | P27037 | 2/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 3/20 | 0.31 |
| ▸ | JAK1 | P23458 | 3/20 | 0.31 |
| ▸ | JAK3 | P52333 | 3/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.30 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.30 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.30 |
| ▸ | CDK1 | P06493 | 2/20 | 0.30 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2750991 | 0.83 | PDPK1 (0.39) | CDK2CCNA2WNT1GSK3BDYRK1A | |
| SCHEMBL2750996 | 0.73 | PTGDR2 (0.38) | CDK2CCNA2WNT1GSK3BDYRK1A | |
| SCHEMBL2752577 | 0.71 | PDPK1 (0.38) | CDK2CCNA2WNT1GSK3BDYRK1A | |
| SCHEMBL2277440 | 0.70 | PDPK1 (0.37) | CDK2CCNA2WNT1GSK3BDYRK1A | |
| SCHEMBL2277448 | 0.70 | PDPK1 (0.37) | CDK2CCNA2WNT1GSK3BDYRK1A | |
| SCHEMBL2278431 | 0.69 | WNT1 (0.38) | CDK2CCNA2WNT1GSK3BDYRK1A | |
| SCHEMBL1800464 | 0.68 | HTR6 (0.33) | — | |
| SCHEMBL2753851 | 0.68 | ROCK2 (0.55) | LRRK2JAK3 | |
| SCHEMBL1801778 | 0.68 | BRD4 (0.44) | CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL2278435 | 0.68 | AXL (0.46) | CDK2CCNA2WNT1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110195951-A1 | DIAZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195951-A1 | DIAZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | DAPK1, DAPK2, DAPK3 | CDK2 46/4885CCNA2 669/4885WNT1 2535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.