SCHEMBL2277488

SCHEMBL2277488

C=C([SiH3])c1ccccc1N(CC)CC

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 5/20 0.34
SMN1; SMN2 Q16637 3/20 0.34
TSHR P16473 3/20 0.34
MAPT P10636 2/20 0.34
ALDH1A1 P00352 2/20 0.34
GAA P10253 1/20 0.34
HTT P42858 1/20 0.34
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
LMNA P02545 1/20 0.33
NFKB1 P19838 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
CYP3A4 P08684 1/20 0.32
NOX1 Q9Y5S8 1/20 0.32
AR P10275 1/20 0.31
BRPF1 P55201 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3274550 0.84 TP53 (0.36) TP53SMN1; SMN2TSHRMAPTALDH1A1
SCHEMBL2276689 0.84 ALDH1A1 (0.33) ALDH1A1CYP3A4
SCHEMBL136256 0.82 TP53 (0.35) TP53SMN1; SMN2TSHRMAPTALDH1A1
SCHEMBL9126049 0.81 TP53 (0.38) TP53SMN1; SMN2TSHRMAPTALDH1A1
SCHEMBL2493417 0.79 TSHR (0.42) TP53SMN1; SMN2TSHRMAPTALDH1A1
SCHEMBL9123840 0.78 MEN1 (0.42) TP53SMN1; SMN2TSHRMAPTALDH1A1
SCHEMBL2267690 0.78 MAPT (0.57) TP53SMN1; SMN2TSHRMAPTALDH1A1
SCHEMBL11754189 0.77 MAPT (0.33) TP53SMN1; SMN2TSHRMAPTALDH1A1
SCHEMBL7673381 0.76 TP53 (0.36) TP53SMN1; SMN2TSHRMAPTALDH1A1
SCHEMBL166160 0.76 TP53 (0.61) TP53SMN1; SMN2TSHRMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed