Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 11/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22776994 | 1.00 | TRPM8 (0.50) | TRPM8CHRM3NAMPTKCNH2PRMT5 | |
| SCHEMBL30965926 | 1.00 | TRPM8 (0.50) | TRPM8CHRM3NAMPTKCNH2PRMT5 | |
| SCHEMBL22776992 | 1.00 | TRPM8 (0.50) | TRPM8CHRM3NAMPTKCNH2PRMT5 | |
| SCHEMBL29271778 | 0.91 | NAMPT (0.61) | TRPM8CHRM3NAMPTKCNH2 | |
| SCHEMBL29271783 | 0.91 | NAMPT (0.61) | TRPM8CHRM3NAMPTKCNH2 | |
| SCHEMBL28686102 | 0.88 | CHRM3 (0.54) | TRPM8CHRM3KCNH2 | |
| SCHEMBL28686100 | 0.88 | CHRM3 (0.54) | TRPM8CHRM3KCNH2 | |
| SCHEMBL28932767 | 0.81 | CHRM3 (0.60) | TRPM8CHRM3NAMPTKCNH2 | |
| SCHEMBL30965923 | 0.81 | CHRM3 (0.59) | TRPM8CHRM3NAMPTKCNH2 | |
| SCHEMBL28695792 | 0.81 | CHRM3 (0.59) | TRPM8CHRM3NAMPTKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113950477-B | Granulin precursor modulators and methods of use thereof | 阿库达医疗公司 | 2024-07-05 | — | — | CN | disclosed |
| EP-3983401-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | Arkuda Therapeutics (US) | 2022-04-20 | — | — | EP | disclosed |
| CN-113950477-A | Modulators of progranulin and methods of use thereof | 阿库达医疗公司 | 2022-01-18 | — | — | CN | disclosed |
| WO-2020252222-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2020-12-17 | — | — | WO | disclosed |
| WO-2020252222-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2020-12-17 | — | — | WO | disclosed |