Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.53 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.53 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.53 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24461790 | 1.00 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1HPGDSTHRB | |
| SCHEMBL24461526 | 0.87 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1HPGDSTHRB | |
| SCHEMBL29619399 | 0.87 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1HPGDSTHRB | |
| SCHEMBL23581053 | 0.85 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1HPGDSTHRB | |
| SCHEMBL22777626 | 0.83 | SMARCA2 (0.54) | SMARCA2SMARCA4PBRM1HPGDSTHRB | |
| SCHEMBL24461562 | 0.82 | MAPT (0.47) | HPGDSTHRBKDM4EMAPTJAK2 | |
| SCHEMBL24838421 | 0.80 | SMARCA2 (0.46) | SMARCA2SMARCA4PBRM1KDM4EGPR119 | |
| SCHEMBL24838350 | 0.80 | SMARCA2 (0.46) | SMARCA2SMARCA4PBRM1KDM4EGPR119 | |
| SCHEMBL24837880 | 0.80 | SMARCA2 (0.46) | SMARCA2SMARCA4PBRM1KDM4EGPR119 | |
| SCHEMBL24838437 | 0.80 | SMARCA2 (0.46) | SMARCA2SMARCA4PBRM1KDM4EGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109426-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2022-05-27 | — | — | WO | disclosed |