Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.47 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 14/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24461134 | 0.94 | BRD4 (0.56) | BRD4KDM4EALDH1A1POLBCREBBP | |
| SCHEMBL24461129 | 0.92 | SMARCA2 (0.45) | BRD4KDM4EALDH1A1POLBCREBBP | |
| SCHEMBL24461486 | 0.83 | HSD11B1 (0.38) | BRD4SMARCA2SMARCA4PBRM1HSD11B1 | |
| SCHEMBL22790943 | 0.83 | CYP1A2 (0.49) | KDM4ESMARCA2SMARCA4PBRM1 | |
| SCHEMBL24461322 | 0.83 | SMARCA2 (0.37) | BRD4SMARCA2SMARCA4PBRM1HSD11B1 | |
| SCHEMBL22777626 | 0.83 | SMARCA2 (0.54) | BRD4KDM4EALDH1A1POLBCREBBP | |
| SCHEMBL24461432 | 0.82 | SMARCA2 (0.37) | BRD4SMARCA2SMARCA4PBRM1HSD11B1 | |
| SCHEMBL24461462 | 0.82 | CAMKK2 (0.40) | BRD4SMARCA2SMARCA4PBRM1HSD11B1 | |
| SCHEMBL24461458 | 0.81 | SMARCA2 (0.36) | BRD4SMARCA2SMARCA4PBRM1HSD11B1 | |
| SCHEMBL24461315 | 0.81 | KDM4E (0.39) | BRD4KDM4ESMARCA2SMARCA4PBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240024488-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2024-01-25 | — | — | US | disclosed |
| US-20240024488-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2024-01-25 | — | — | US | disclosed |
| WO-2022109426-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2022-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240024488-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | BRD4 111/4885KDM4E 1848/4885ALDH1A1 2571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.