SCHEMBL22777967

SCHEMBL22777967

CC(C)(C)[Si](C)(C)n1cc(F)c2ccc(Br)cc21

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PDGFRA P16234 1/20 0.33
CDK5 Q00535 1/20 0.33
TYRO3 Q06418 1/20 0.33
APLNR P35414 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29714438 1.00 PDGFRA (0.33) PDGFRACDK5TYRO3APLNR
SCHEMBL22778008 0.77 HCAR3 (0.41)
SCHEMBL20348686 0.74 PDGFRA (0.37) PDGFRACDK5TYRO3APLNR
SCHEMBL31550346 0.74 PDGFRA (0.37) PDGFRACDK5TYRO3APLNR
SCHEMBL21816695 0.73 CYP19A1 (0.36) PDGFRACDK5TYRO3
SCHEMBL6510985 0.71 PDE4B (0.33) APLNR
SCHEMBL4142457 0.71 MAPT (0.34)
SCHEMBL29331361 0.69 USP30 (0.42) PDGFRACDK5TYRO3
SCHEMBL18191223 0.67 MAPT (0.41) PDGFRACDK5TYRO3
SCHEMBL444893 0.67 SLC6A2 (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230092163-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2023-03-23 US disclosed
EP-3983383-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM Due, Inc. (US) 2022-04-20 EP disclosed
WO-2020252240-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM DUE, INC. (US) 2020-12-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230092163-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY STING1, CGAS, IRF3 PDGFRA 2172/4885CDK5 3226/4885TYRO3 3327/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.