Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 4/20 | 0.58 |
| ▸ | DRD2 | P14416 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5658350 | 0.83 | HTR7 (0.64) | HDAC3HDAC1HDAC10HDAC11ALDH1A1 | |
| SCHEMBL13059439 | 0.82 | HDAC3 (0.67) | HDAC3HDAC1HDAC10HDAC11ALDH1A1 | |
| SCHEMBL26450841 | 0.81 | NOTUM (0.66) | HDAC3HDAC1HDAC10HDAC11ALDH1A1 | |
| SCHEMBL5655873 | 0.81 | HTR1A (0.72) | ALDH1A1HPGDHTR1ADRD2TSHR | |
| SCHEMBL6228768 | 0.80 | HDAC3 (0.68) | HDAC3HDAC1HDAC10HDAC11ALDH1A1 | |
| SCHEMBL4636681 | 0.80 | HTR1A (0.60) | HTR1ADRD2 | |
| SCHEMBL5657585 | 0.80 | HTR1A (0.55) | HDAC3HDAC1HDAC10HDAC11HPGD | |
| SCHEMBL3721168 | 0.80 | PRMT5 (0.56) | ALDH1A1HPGDTSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL3703522 | 0.79 | NAMPT (0.87) | ALDH1A1MAPTSMN1; SMN2NAMPTKDM4E | |
| SCHEMBL13487712 | 0.79 | HDAC3 (0.67) | HDAC3HDAC1HDAC10HDAC11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252222-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2020-12-17 | — | — | WO | disclosed |