Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.61 |
| ▸ | JAK2 | O60674 | 7/20 | 0.43 |
| ▸ | TYK2 | P29597 | 5/20 | 0.39 |
| ▸ | JAK3 | P52333 | 5/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2228322 | 0.85 | JAK1 (0.52) | JAK1JAK2TYK2JAK3BCHE | |
| SCHEMBL2279088 | 0.84 | JAK1 (0.62) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2271087 | 0.84 | JAK1 (0.45) | JAK1JAK2TYK2JAK3BCHE | |
| SCHEMBL2276970 | 0.81 | JAK1 (0.50) | JAK1JAK2TYK2JAK3HTR6 | |
| SCHEMBL2270472 | 0.80 | JAK1 (0.68) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2275931 | 0.80 | HTR6 (0.48) | JAK1JAK2TYK2JAK3BCHE | |
| SCHEMBL2223793 | 0.79 | JAK1 (0.54) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2282946 | 0.79 | JAK1 (0.54) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2279223 | 0.78 | JAK1 (0.42) | JAK1JAK2TYK2JAK3HTR6 | |
| SCHEMBL2276856 | 0.78 | JAK1 (0.41) | JAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |