Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 14/20 | 0.44 |
| ▸ | JAK2 | O60674 | 6/20 | 0.44 |
| ▸ | JAK3 | P52333 | 6/20 | 0.44 |
| ▸ | TYK2 | P29597 | 5/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2274847 | 0.83 | JAK1 (0.51) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2281350 | 0.81 | JAK1 (0.45) | JAK1JAK2JAK3TYK2PIK3CA | |
| SCHEMBL2273996 | 0.79 | JAK1 (0.41) | JAK1JAK2JAK3TYK2PIK3CA | |
| SCHEMBL2226011 | 0.79 | JAK1 (0.47) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2279021 | 0.78 | JAK1 (0.64) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2280484 | 0.77 | JAK1 (0.39) | JAK1JAK2JAK3TYK2PIK3CA | |
| SCHEMBL2226408 | 0.73 | HTR6 (0.42) | PIK3CACYP11B2MMP2MMP13GPR119 | |
| SCHEMBL2275311 | 0.73 | JAK1 (0.62) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2275456 | 0.73 | JAK1 (0.49) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2272285 | 0.72 | JAK1 (0.62) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |