Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1517086 | 0.85 | EPHX2 (0.43) | LMNAEPHX2GAAMAPK1MAPT | |
| SCHEMBL695370 | 0.78 | KDM4E (0.44) | LMNAGAAMAPK1MAPTL3MBTL1 | |
| SCHEMBL12256403 | 0.77 | CA1 (0.39) | LMNAEPHX2GAAMAPTL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL19857506 | 0.77 | EPHX2 (0.43) | LMNAEPHX2GAAMAPK1MAPT | |
| Hydrochloric Acid SCHEMBL29903895 | 0.77 | KDM4E (0.43) | LMNAGAAMAPK1MAPTL3MBTL1 | |
| SCHEMBL22787386 | 0.76 | PDK1 (0.33) | ALDH1A1PDK1PDK2PDK3PDK4 | |
| SCHEMBL2423436 | 0.75 | ALOX5AP (0.32) | LMNAGAAMAPK1MAPTL3MBTL1 | |
| SCHEMBL1516954 | 0.72 | ALDH1A1 (0.50) | LMNAGAAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL22860158 | 0.71 | EPHX2 (0.41) | LMNAEPHX2GAAMAPTJAK2 | |
| Trifluoroacetic Acid SCHEMBL6039700 | 0.71 | ALDH1A1 (0.47) | LMNAEPHX2GAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11396512-B2 | CDK2/4/6 inhibitors | PFIZER INC. (US) | 2022-07-26 | — | — | US | disclosed |
| US-20200392142-A1 | CDK2/4/6 Inhibitors | PFIZER INC. (US) | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200392142-A1 | CDK2/4/6 Inhibitors | CDK2, CDK6, CDK20 | LMNA 2249/4885EPHX2 3656/4885GAA 3214/4885 |
| US-11396512-B2 | CDK2/4/6 inhibitors | CDK2, CDK6, CDK20 | LMNA 2211/4885EPHX2 3664/4885GAA 3247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.