Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19650813 | 0.88 | KDM1A (0.59) | KDM1AMAOAMAOBHDAC1HDAC8 | |
| SCHEMBL29456936 | 0.88 | KDM1A (0.59) | KDM1AMAOAMAOBHDAC1HDAC8 | |
| Hydrochloric Acid SCHEMBL30615191 | 0.86 | KDM1A (0.58) | KDM1AMAOAMAOBHDAC1HDAC8 | |
| SCHEMBL25374816 | 0.82 | KDM1A (0.54) | KDM1AMAOAMAOBHDAC1HDAC8 | |
| SCHEMBL22787439 | 0.82 | KDM1A (0.45) | KDM1AMAOAMAOBHDAC1HDAC8 | |
| SCHEMBL30471935 | 0.82 | KDM1A (0.56) | KDM1AMAOAMAOBHDAC1HDAC8 | |
| SCHEMBL23545585 | 0.82 | KDM1A (0.56) | KDM1AMAOAMAOBHDAC1HDAC8 | |
| SCHEMBL24468271 | 0.78 | KDM1A (0.53) | KDM1AMAOAMAOBHDAC1HDAC8 | |
| SCHEMBL24258285 | 0.76 | BCHE (0.50) | KDM1AMAOAMAOBHDAC1RAB9A | |
| SCHEMBL20839220 | 0.76 | SMYD3 (0.44) | KDM1AMAOAMAOBHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11254681-B2 | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases | NUEVOLUTION A/S (DK) | 2022-02-22 | — | — | US | disclosed |
| US-20200392140-A1 | OPTIONALLY FUSED HETEROCYCLYL- SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES | NUEVOLUTION A/S (DK) | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11254681-B2 | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases | PPARD, PPARG, RORC | KDM1A 4158/4885MAOA 3153/4885MAOB 2382/4885 |
| US-20200392140-A1 | OPTIONALLY FUSED HETEROCYCLYL- SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES | PPARD, PPARG, RORC | KDM1A 4158/4885MAOA 3153/4885MAOB 2382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.