Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 12/20 | 0.75 |
| ▸ | UBA3 | Q8TBC4 | 12/20 | 0.75 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.49 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22787594 | 0.86 | NAE1 (1.00) | NAE1UBA3 | |
| SCHEMBL22787515 | 0.83 | NAE1 (0.75) | NAE1UBA3ADORA3SLC29A1ADORA2A | |
| SCHEMBL22787574 | 0.81 | NAE1 (0.75) | NAE1UBA3ALDH1A1 | |
| SCHEMBL24286006 | 0.78 | NAE1 (0.75) | NAE1UBA3ADORA3ADORA2AADORA2B | |
| SCHEMBL22787476 | 0.78 | NAE1 (1.00) | NAE1UBA3 | |
| SCHEMBL22787559 | 0.76 | NAE1 (0.73) | NAE1UBA3SLC29A1 | |
| SCHEMBL22787484 | 0.75 | NAE1 (0.49) | NAE1UBA3 | |
| SCHEMBL24286197 | 0.75 | NAE1 (0.46) | NAE1UBA3ADORA3SLC29A1ADORA2A | |
| SCHEMBL24286183 | 0.73 | NAE1 (0.75) | NAE1UBA3 | |
| SCHEMBL22787469 | 0.73 | AHCY (0.48) | NAE1UBA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020249109-A1 | TRIAZOLOPYRIMIDINE COMPOUND AND SALT, COMPOSITION AND USE THEREOF | 中国科学院上海药物研究所 | 2020-12-17 | — | — | WO | disclosed |