Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9742313 | 0.81 | HSD11B1 (0.41) | HSD11B1EPHX2MGAMGAASI | |
| SCHEMBL3712186 | 0.81 | SIRT5 (0.42) | HSD11B1EPHX2MGAMGAASI | |
| SCHEMBL2747443 | 0.80 | HSD11B1 (0.57) | HSD11B1EPHX2L3MBTL1KMT2A | |
| SCHEMBL3902691 | 0.79 | CYP1A2 (0.46) | HSD11B1EPHX2ALDH1A1L3MBTL1CYP1A2 | |
| SCHEMBL18045654 | 0.79 | HSD11B1 (0.47) | HSD11B1EPHX2ALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL3753078 | 0.78 | MGAM (0.43) | EPHX2MGAMGAASIMGAM2 | |
| SCHEMBL18979943 | 0.78 | GAA (0.39) | EPHX2MGAMGAASIMGAM2 | |
| SCHEMBL26606177 | 0.78 | GAA (0.39) | EPHX2MGAMGAASIMGAM2 | |
| Hydrochloric Acid SCHEMBL23930684 | 0.77 | MGAM (0.38) | EPHX2MGAMGAASIMGAM2 | |
| SCHEMBL19010963 | 0.77 | MGAM (0.38) | EPHX2MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116745267-A | Benzimidazole derivatives for the treatment of respiratory diseases | 跨膜蛋白16A有限公司 | 2023-09-12 | — | — | CN | disclosed |
| WO-2022123314-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING RESPIRATORY DISEASE | TMEM16A LIMITED (GB) | 2022-06-16 | — | — | WO | disclosed |
| CN-114269721-A | Compounds for the treatment of respiratory diseases | TMEM16A有限公司 | 2022-04-01 | — | — | CN | disclosed |
| WO-2020249957-A1 | COMPOUNDS FOR TREATING RESPIRATORY DISEASE | Enterprise Therapeutics Limited (GB) | 2020-12-17 | — | — | WO | disclosed |