Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL778548 | 0.80 | NLRP3 (0.36) | NLRP3 | |
| SCHEMBL2625547 | 0.77 | NLRP3 (0.38) | NLRP3 | |
| SCHEMBL19764245 | 0.76 | PTGS1 (0.38) | — | |
| SCHEMBL20499363 | 0.76 | — | — | |
| SCHEMBL14151428 | 0.72 | GRM4 (0.37) | NLRP3CA1 | |
| SCHEMBL21557564 | 0.72 | — | — | |
| SCHEMBL24685655 | 0.72 | CES1 (0.33) | — | |
| SCHEMBL31310570 | 0.71 | — | — | |
| SCHEMBL14814813 | 0.70 | ALDH1A1 (0.35) | NLRP3 | |
| SCHEMBL14003210 | 0.70 | NLRP3 (0.33) | NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252165-A1 | QUINAZOLINYL COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2020-12-17 | — | — | WO | disclosed |