Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 7/20 | 0.40 |
| ▸ | KHK | P50053 | 2/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | MAP2 | P11137 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22790093 | 0.82 | NR4A2 (0.52) | MEN1KMT2AKDM4EKHKSIRT6 | |
| SCHEMBL22790352 | 0.78 | NR4A2 (0.48) | MEN1KMT2AKDM4EHTR6KHK | |
| SCHEMBL22790247 | 0.77 | KMT2A (0.44) | MEN1KMT2AKDM4ENR4A2 | |
| SCHEMBL12306058 | 0.71 | MYC (0.57) | MEN1KMT2AKDM4ESIRT6ADRB1 | |
| SCHEMBL15547292 | 0.71 | ADRB1 (0.58) | MEN1KMT2AKDM4EHTR6SIRT6 | |
| SCHEMBL7653332 | 0.71 | ADRB1 (0.58) | MEN1KMT2AKDM4EHTR6SIRT6 | |
| SCHEMBL1958199 | 0.70 | KDM4E (0.47) | MEN1KMT2AKDM4EHTR6SIRT6 | |
| SCHEMBL19579582 | 0.70 | ACVR1 (0.51) | MEN1KMT2AKDM4ESIRT6ADRB1 | |
| SCHEMBL7652198 | 0.70 | ACVR1 (0.47) | MEN1KMT2AKDM4ESIRT6ADRB1 | |
| SCHEMBL25727525 | 0.70 | KDM4E (0.47) | MEN1KMT2AKDM4EHTR6SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020249064-A1 | COMPOUNDS FOR MODULATING FXR | NANJING RUIJIE PHARMA CO., LTD. (CN) | 2020-12-17 | — | — | WO | disclosed |