Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRPS1 | P60891 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565888 | 0.81 | NR4A2 (0.60) | L3MBTL1NR4A2KMT2AMEN1TSHR | |
| SCHEMBL498716 | 0.80 | PRPS1 (0.45) | PRPS1L3MBTL1NR4A2KMT2AMEN1 | |
| SCHEMBL22790237 | 0.80 | NR4A2 (0.41) | L3MBTL1NR4A2KMT2AMEN1ELANE | |
| SCHEMBL497718 | 0.78 | NR4A2 (0.63) | PRPS1L3MBTL1NR4A2KMT2AMEN1 | |
| SCHEMBL22790247 | 0.77 | KMT2A (0.44) | PRPS1L3MBTL1NR4A2KMT2AMEN1 | |
| SCHEMBL12127680 | 0.77 | L3MBTL1 (0.37) | L3MBTL1NR4A2KMT2AMEN1ALDH1A1 | |
| SCHEMBL15025087 | 0.76 | PDGFRA (0.35) | CHEK1HTTLMNASMN1; SMN2 | |
| SCHEMBL21549969 | 0.75 | NR4A2 (0.66) | PRPS1L3MBTL1NR4A2KMT2AMEN1 | |
| SCHEMBL35211208 | 0.75 | NR4A2 (0.66) | PRPS1L3MBTL1NR4A2KMT2AMEN1 | |
| SCHEMBL15024961 | 0.74 | PDGFRA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020249064-A1 | COMPOUNDS FOR MODULATING FXR | NANJING RUIJIE PHARMA CO., LTD. (CN) | 2020-12-17 | — | — | WO | disclosed |