Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 9/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35210953 | 1.00 | MAP2K1 (0.45) | MAP2K1MAP2K2POLBMCL1MYC | |
| SCHEMBL35211364 | 0.84 | NR4A2 (0.46) | MAP2K1MAP2K2MEN1KMT2AALDH1A1 | |
| SCHEMBL22790396 | 0.84 | NR4A2 (0.46) | MAP2K1MAP2K2MEN1KMT2AALDH1A1 | |
| SCHEMBL35211202 | 0.81 | MAP2K1 (0.35) | MAP2K1POLBMYCNR4A1GPR17 | |
| SCHEMBL26691558 | 0.78 | NR4A2 (0.46) | MAP2K1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL2439783 | 0.74 | POLB (0.47) | POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL35210914 | 0.73 | ALDH1A1 (0.46) | POLBMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1020529 | 0.73 | MAP2K1 (0.52) | MAP2K1POLBMCL1MEN1KMT2A | |
| SCHEMBL1096533 | 0.72 | CDK2 (0.49) | MAP2K1POLBMCL1MYCNR4A1 | |
| SCHEMBL2587254 | 0.72 | AKR1C3 (0.36) | MAP2K1POLBMCL1MYCNR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125391-A1 | PYRIMIDINE INDOLES AS CDK4 INHIBITORS | INCYTE CORP (US) | 2026-05-07 | — | — | US | disclosed |
| WO-2020249064-A1 | COMPOUNDS FOR MODULATING FXR | NANJING RUIJIE PHARMA CO., LTD. (CN) | 2020-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260125391-A1 | PYRIMIDINE INDOLES AS CDK4 INHIBITORS | CDK4, CCNA1, CCNO | MAP2K1 252/4885MAP2K2 233/4885POLB 247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.