Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.33 |
| ▸ | HTR1B | P28222 | 2/20 | 0.33 |
| ▸ | ERN1 | O75460 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2537941 | 0.83 | ALDH1A1 (0.53) | ALDH1A1KDM4EIMPDH2HTR1DHTR1B | |
| SCHEMBL35210764 | 0.81 | ALDH1A1 (0.33) | ALDH1A1KDM4EERN1 | |
| SCHEMBL24330123 | 0.74 | ALDH1A1 (0.42) | ALDH1A1KDM4EIMPDH2ERN1POLB | |
| SCHEMBL1093446 | 0.73 | ALDH1A1 (0.54) | ALDH1A1KDM4EIMPDH2HTR1DHTR1B | |
| SCHEMBL22790397 | 0.73 | MAP2K1 (0.45) | ALDH1A1KDM4EMEN1POLBKMT2A | |
| SCHEMBL35210953 | 0.73 | MAP2K1 (0.45) | ALDH1A1KDM4EMEN1POLBKMT2A | |
| SCHEMBL2534461 | 0.71 | ALDH1A1 (0.44) | ALDH1A1KDM4EIMPDH2HTR1DHTR1B | |
| SCHEMBL16502064 | 0.70 | ALDH1A1 (0.62) | ALDH1A1KDM4EIMPDH2ERN1 | |
| SCHEMBL22790396 | 0.70 | NR4A2 (0.46) | ALDH1A1MEN1KMT2A | |
| SCHEMBL35211364 | 0.70 | NR4A2 (0.46) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125391-A1 | PYRIMIDINE INDOLES AS CDK4 INHIBITORS | INCYTE CORP (US) | 2026-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260125391-A1 | PYRIMIDINE INDOLES AS CDK4 INHIBITORS | CDK4, CCNA1, CCNO | ALDH1A1 577/4885KDM4E 1827/4885IMPDH2 2284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.