Sugi Predict

Sugi Predict / Compounds / SCHEMBL22790508

SCHEMBL22790508

SCHEMBL22790508

CCCCC(=O)Nc1c(Cl)nc2ccccc2c1NCc1ccc(CNC(=O)OC(C)(C)C)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TLR7 Q9NYK1 5/20 0.48
▸ GAA P10253 4/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ NPC1 O15118 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ ALDH1A1 P00352 3/20 0.43
▸ HPGD P15428 3/20 0.43
▸ KDM4E B2RXH2 2/20 0.43
▸ CTSK P43235 1/20 0.41
▸ TSHR P16473 1/20 0.41
▸ HSD17B10 Q99714 1/20 0.41
▸ ACACB O00763 1/20 0.41
▸ ACACA Q13085 1/20 0.41
▸ NAMPT P43490 2/20 0.40
▸ TOP2A P11388 1/20 0.40
▸ TOP2B Q02880 1/20 0.40
▸ GBA1 P04062 1/20 0.40
▸ CA1 P00915 1/20 0.40
▸ CA2 P00918 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29378988 0.95 GAA (0.46) TLR7GAAMEN1NPC1RAB9A
SCHEMBL20801390 0.89 TLR7 (0.51) TLR7GAAMEN1NPC1RAB9A
SCHEMBL21632144 0.89 GAA (0.47) TLR7GAARAB9AKMT2AALDH1A1
SCHEMBL22181053 0.85 TLR7 (0.48) TLR7GAAMEN1NPC1RAB9A
SCHEMBL29947639 0.84 TLR7 (0.42) TLR7GAAMEN1NPC1RAB9A
SCHEMBL29136619 0.84 TLR7 (0.42) TLR7GAAMEN1NPC1RAB9A
SCHEMBL21632097 0.84 KDM4E (0.43) TLR7GAARAB9AALDH1A1HPGD
SCHEMBL20766797 0.83 GAA (0.47) GAARAB9AKMT2AALDH1A1HPGD
SCHEMBL21649103 0.81 KMT2A (0.51) GAAMEN1NPC1RAB9AKMT2A
SCHEMBL21013099 0.81 KMT2A (0.50) TLR7GAAMEN1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11744876-B2 Immunomodulator antibody drug conjugates and uses thereof SUTRO BIOPHARMA, INC. (US) 2023-09-05 — — US disclosed
US-11744876-B2 Immunomodulator antibody drug conjugates and uses thereof SUTRO BIOPHARMA, INC. (US) 2023-09-05 — — US disclosed
US-20210213010-A1 TLR7/8 AGONISTS AND LIPOSOME COMPOSITIONS DANMARKS TEKNISKE UNIVERSITET (DK) 2021-07-15 — — US disclosed
US-20200405813-A1 IMMUNOMODULATOR ANTIBODY DRUG CONJUGATES AND USES THEREOF SUTRO BIOPHARMA, INC. 2020-12-31 — — US disclosed
WO-2020252015-A1 IMMUNOMODULATOR ANTIBODY DRUG CONJUGATES AND USES THEREOF SUTRO BIOPHARMA, INC. (US) 2020-12-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210213010-A1 TLR7/8 AGONISTS AND LIPOSOME COMPOSITIONS TLR7, TLR9, TLR8 TLR7 1/4885GAA 1315/4885MEN1 2845/4885
US-11744876-B2 Immunomodulator antibody drug conjugates and uses thereof FCGR1A, FCGR2A, FCGRT TLR7 210/4885GAA 544/4885MEN1 4427/4885
US-20200405813-A1 IMMUNOMODULATOR ANTIBODY DRUG CONJUGATES AND USES THEREOF FCGR2A, FCGR1A, FCGR3B TLR7 212/4885GAA 505/4885MEN1 4395/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.