Sugi Predict

Sugi Predict / Compounds / SCHEMBL22790690

SCHEMBL22790690

SCHEMBL22790690

CC(C)CCCN1CC2(CCN(C(=O)C(C)C)CC2)C1

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ CYP2D6 P10635 11/20 0.41
▸ TSHR P16473 4/20 0.40
▸ USP2 O75604 7/20 0.39
▸ CYP1A2 P05177 5/20 0.39
▸ CYP2C9 P11712 3/20 0.39
▸ HIF1A Q16665 2/20 0.39
▸ CYP2C19 P33261 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.38
▸ CYP3A4 P08684 9/20 0.36
▸ ALOX15 P16050 1/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ FPR3 P25089 1/20 0.34
▸ FPR2 P25090 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22856411 0.91 CYP2D6 (0.43) CYP2D6TSHRUSP2CYP1A2CYP2C9
SCHEMBL23696050 0.90 CYP2D6 (0.46) CYP2D6TSHRCYP1A2CYP2C9CYP3A4
SCHEMBL23695981 0.89 CYP2D6 (0.37) CYP2D6TSHRUSP2CYP1A2CYP2C9
SCHEMBL22904931 0.88 CYP2D6 (0.38) CYP2D6TSHRUSP2CYP1A2CYP2C9
SCHEMBL24508582 0.87 HRH2 (0.41) CYP2D6TSHRUSP2CYP1A2CYP2C9
SCHEMBL22848882 0.87 CYP2D6 (0.44) CYP2D6TSHRUSP2CYP1A2CYP2C9
SCHEMBL25469223 0.84 S1PR1 (0.43) CYP2D6TSHRUSP2CYP1A2CYP2C9
SCHEMBL24508729 0.84 FPR3 (0.38) CYP2D6TSHRUSP2CYP1A2CYP2C9
SCHEMBL22849045 0.83 CYP2D6 (0.41) CYP2D6TSHRUSP2CYP1A2CYP2C9
SCHEMBL25110655 0.83 CYP2D6 (0.36) CYP2D6TSHRUSP2CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240024318-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2024-01-25 — — US disclosed
US-20240024318-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2024-01-25 — — US disclosed
US-11807636-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2023-11-07 — — US disclosed
US-11807636-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2023-11-07 — — US disclosed
US-11779578-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2023-10-10 — — US disclosed
US-11779578-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2023-10-10 — — US disclosed
WO-2023192578-A1 PROTEIN DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2023-10-05 — — WO disclosed
US-20230303526-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-09-28 — — US disclosed
US-20230303526-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-09-28 — — US disclosed
US-11746120-B2 Stat degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2023-09-05 — — US disclosed
US-20230135894-A1 MK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-05-04 — — US disclosed
US-20230135894-A1 MK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-05-04 — — US disclosed
US-20230072658-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-03-09 — — US disclosed
US-20220340570-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2022-10-27 — — US disclosed
US-11352350-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2022-06-07 — — US disclosed
US-20210323952-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2021-10-21 — — US disclosed
US-11117889-B1 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2021-09-14 — — US disclosed
US-20210228562-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2021-07-29 — — US disclosed
WO-2021127190-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2021-06-24 — — WO disclosed
WO-2020251972-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2020-12-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230135894-A1 MK2 DEGRADERS AND USES THEREOF MKNK2, MKRN3, DUS2 CYP2D6 474/4885TSHR 3916/4885USP2 105/4885
US-20240024318-A1 SMARCA DEGRADERS AND USES THEREOF SMARCA1, SMARCA2, SMARCC2 CYP2D6 2910/4885TSHR 4388/4885USP2 1076/4885
US-11117889-B1 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK1 CYP2D6 3599/4885TSHR 3319/4885USP2 141/4885
US-11352350-B2 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK1 CYP2D6 3599/4885TSHR 3319/4885USP2 141/4885
US-20210323952-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 CYP2D6 3599/4885TSHR 3319/4885USP2 141/4885
US-11746120-B2 Stat degraders and uses thereof STAT4, STAT1, STAT3 CYP2D6 698/4885TSHR 1768/4885USP2 519/4885
US-20220340570-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 CYP2D6 3599/4885TSHR 3319/4885USP2 141/4885
US-11807636-B2 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK1 CYP2D6 3599/4885TSHR 3319/4885USP2 141/4885
US-20210228562-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 CYP2D6 3599/4885TSHR 3319/4885USP2 141/4885
US-20230303526-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 CYP2D6 3599/4885TSHR 3319/4885USP2 141/4885
US-11779578-B2 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK1 CYP2D6 3599/4885TSHR 3319/4885USP2 141/4885
US-20230072658-A1 SMARCA DEGRADERS AND USES THEREOF SMARCA1, SMARCB1, SMARCE1 CYP2D6 4577/4885TSHR 3796/4885USP2 207/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.