Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25108481 | 0.95 | HRH3 (0.45) | KDM4EMAPTALDH1A1PKMHRH3 | |
| SCHEMBL25468371 | 0.93 | HRH3 (0.47) | KDM4EMAPTALDH1A1PKMHRH3 | |
| SCHEMBL25111065 | 0.91 | MAPT (0.41) | KDM4EMAPTALDH1A1PKMHRH3 | |
| SCHEMBL25111066 | 0.88 | CHKA (0.46) | KDM4EMAPTALDH1A1KMT2AGAA | |
| SCHEMBL25110787 | 0.87 | HRH3 (0.43) | KDM4EMAPTALDH1A1PKMHRH3 | |
| SCHEMBL25481181 | 0.86 | HRH3 (0.44) | KDM4EMAPTALDH1A1PKMHRH3 | |
| SCHEMBL25481321 | 0.83 | RORC (0.35) | MAPTHRH3KMT2AHTR1DHTR1B | |
| SCHEMBL22802982 | 0.81 | RORC (0.43) | HTR1DHTR1BRORC | |
| SCHEMBL25108483 | 0.79 | CHKA (0.50) | KDM4EMAPTALDH1A1KMT2AGAA | |
| SCHEMBL25108491 | 0.79 | CHKA (0.40) | KMT2AGAAHTR1DHTR1BRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125804-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |
| WO-2020251971-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |
| WO-2020251972-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |