Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.43 |
| ▸ | CHKA | P35790 | 2/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | LSS | P48449 | 3/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | HTR1B | P28222 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25111065 | 0.91 | MAPT (0.41) | RORCHTR1DHTR1B | |
| SCHEMBL25108491 | 0.88 | CHKA (0.40) | RORCCHKANCF1LSSHTR1D | |
| SCHEMBL25481321 | 0.88 | RORC (0.35) | RORCHTR1DHTR1B | |
| SCHEMBL25111066 | 0.88 | CHKA (0.46) | RORCCHKANCF1LSSHTR1D | |
| SCHEMBL25108483 | 0.87 | CHKA (0.50) | RORCCHKANCF1LSSHDAC1 | |
| SCHEMBL25110795 | 0.84 | RORC (0.44) | RORCCHKANCF1LSSHTR1D | |
| SCHEMBL22794600 | 0.84 | SLC6A2 (0.39) | LSS | |
| SCHEMBL25108882 | 0.83 | MAOB (0.44) | LSSHDAC1 | |
| SCHEMBL22790758 | 0.81 | KDM4E (0.43) | RORCHTR1DHTR1B | |
| SCHEMBL25468371 | 0.80 | HRH3 (0.47) | RORCCHKALSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251969-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |