Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | LITAF | Q99732 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29978778 | 0.86 | STS (0.45) | STSMEN1KMT2ALMNAMAPT | |
| SCHEMBL22776965 | 0.86 | STS (0.45) | STSMEN1KMT2ALMNAMAPT | |
| SCHEMBL16035623 | 0.85 | STS (0.42) | STSMEN1KMT2APTPN2PTPN1 | |
| SCHEMBL16041310 | 0.81 | USP30 (0.40) | STSPTPN2PTPN1PTPN6MAPT | |
| SCHEMBL23580318 | 0.80 | MAPK8 (0.49) | STSMEN1KMT2AMAPT | |
| SCHEMBL16040618 | 0.77 | ATR (0.39) | STSMEN1KMT2APTPN2PTPN1 | |
| SCHEMBL16041151 | 0.76 | ANO1 (0.38) | STSMEN1KMT2APTPN2PTPN1 | |
| SCHEMBL16040957 | 0.74 | NR3C1 (0.39) | STSPTPN2PTPN1PTPN6NR3C1 | |
| SCHEMBL25258371 | 0.74 | GPR119 (0.44) | STSMEN1KMT2AMAPTGPR119 | |
| SCHEMBL22530217 | 0.74 | STS (0.46) | STSMEN1KMT2APTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251974-A1 | SMARCA INHIBITORS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |