Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22792194 | 0.86 | TSHR (0.50) | ALOX15MAPK1TSHRALDH1A1HPGD | |
| SCHEMBL22792188 | 0.84 | BRAF (0.53) | PDGFRBPDGFRACLK4ADORA2A | |
| SCHEMBL22792290 | 0.83 | MEN1 (0.48) | MAPK1ALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL22791987 | 0.81 | VNN1 (0.49) | ALOX15MAPK1TSHRALDH1A1HPGD | |
| SCHEMBL22792283 | 0.81 | MEN1 (0.39) | TSHRALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL22792002 | 0.80 | PTGS2 (0.51) | TSHRALDH1A1 | |
| SCHEMBL22792621 | 0.80 | CYP1A2 (0.54) | ALOX15MAPK1TSHRALDH1A1HPGD | |
| SCHEMBL22792315 | 0.79 | CA1 (0.43) | FYN | |
| SCHEMBL22792671 | 0.79 | VNN1 (0.47) | — | |
| SCHEMBL14416668 | 0.76 | CLK4 (0.51) | HPGDLMNAMAPTCLK4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252229-A2 | INHIBITORS OF SARM1 | DISARM THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |