Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KHK | P50053 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10263497 | 0.81 | TLR7 (0.39) | CYP2D6ALOX5APTLR7PARGTGFBR1 | |
| SCHEMBL12776229 | 0.81 | L3MBTL1 (0.50) | L3MBTL1 | |
| SCHEMBL24393089 | 0.78 | TLR7 (0.38) | TLR7PARGTGFBR1JAK2JAK1 | |
| SCHEMBL26748196 | 0.78 | L3MBTL1 (0.33) | L3MBTL1 | |
| SCHEMBL12092593 | 0.77 | MAPT (0.37) | JAK2JAK1JAK3L3MBTL1KCNH2 | |
| SCHEMBL15978917 | 0.77 | PDK2 (0.35) | JAK2JAK1TYK2JAK3L3MBTL1 | |
| SCHEMBL19821647 | 0.77 | NAMPT (0.38) | L3MBTL1 | |
| SCHEMBL26748195 | 0.77 | L3MBTL1 (0.33) | L3MBTL1 | |
| SCHEMBL10203201 | 0.76 | TGFBR1 (0.40) | CYP2D6ALOX5APTLR7TGFBR1JAK2 | |
| SCHEMBL26748197 | 0.75 | L3MBTL1 (0.32) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252229-A2 | INHIBITORS OF SARM1 | DISARM THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |