Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | LATS1 | O95835 | 9/20 | 0.35 |
| ▸ | LATS2 | Q9NRM7 | 7/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.33 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13233191 | 0.82 | RPS6KA3 (0.36) | RPS6KA3LATS1LATS2USP2HTT | |
| SCHEMBL24249190 | 0.81 | RPS6KA3 (0.42) | RPS6KA3LATS1LATS2MAP4K4MINK1 | |
| SCHEMBL22792741 | 0.78 | RPS6KA3 (0.34) | RPS6KA3LATS1LATS2MAP4K4MINK1 | |
| SCHEMBL13263596 | 0.77 | CSNK1D (0.37) | LATS1LATS2MAP4K4MINK1TNIK | |
| SCHEMBL12388168 | 0.76 | ALDH1A1 (0.55) | HTTPDE10A | |
| SCHEMBL13263764 | 0.75 | MAP4K4 (0.36) | LATS1LATS2USP2HTTNCOA1 | |
| SCHEMBL12778210 | 0.75 | PRKCZ (0.44) | RPS6KA3ALOX5CSNK1DCSNK1ECLK1 | |
| SCHEMBL19070575 | 0.74 | HASPIN (0.38) | MAP4K4MINK1TNIKCSNK1DCSNK1E | |
| SCHEMBL6004354 | 0.74 | HPGD (0.58) | HTTMAP4K4MINK1TNIKCSNK1D | |
| SCHEMBL19068654 | 0.73 | PRKCZ (0.40) | RPS6KA3CSNK1DCSNK1ECLK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10988466-B2 | Heterocyclic derivatives useful as SHP2 inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2021-04-27 | — | — | US | disclosed |
| US-20200392128-A1 | NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10988466-B2 | Heterocyclic derivatives useful as SHP2 inhibitors | PTPRJ, PTPN5, PTPN1 | RPS6KA3 1133/4885LATS1 817/4885LATS2 1046/4885 |
| US-20200392128-A1 | NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | PTPN5, PTPN1, PTPRJ | RPS6KA3 1228/4885LATS1 724/4885LATS2 913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.