Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | RAD52 | P43351 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NT5E | P21589 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12240504 | 0.84 | POLB (1.00) | POLBMAPTKMT2AKDM4EPTGS1 | |
| SCHEMBL23999498 | 0.84 | MAPT (0.51) | POLBMAPTKMT2AKDM4ERAB9A | |
| SCHEMBL24004060 | 0.84 | POLB (0.72) | POLBMAPTKMT2AKDM4ERAB9A | |
| SCHEMBL22242773 | 0.80 | PTGS1 (0.77) | POLBKMT2AKDM4ERAB9APTGS1 | |
| SCHEMBL25466336 | 0.78 | DNMT1 (0.80) | MAPTKMT2AKDM4ERAB9AALDH1A1 | |
| SCHEMBL11613305 | 0.78 | POLB (0.87) | POLBMAPTKMT2AKDM4EPTGS1 | |
| SCHEMBL24003821 | 0.77 | ACVRL1 (0.62) | POLBMAPTKMT2AKDM4ERAB9A | |
| SCHEMBL30232862 | 0.77 | ACVRL1 (0.62) | POLBMAPTKMT2AKDM4ERAB9A | |
| SCHEMBL24004063 | 0.77 | POLB (0.66) | POLBMAPTKMT2AKDM4ERAB9A | |
| SCHEMBL23999623 | 0.76 | KDM4E (0.85) | POLBMAPTKMT2AKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200390884-A1 | Methods and Compositions for Modulating AKT3 | AUGUSTA UNIVERSITY | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200390884-A1 | Methods and Compositions for Modulating AKT3 | AKT3, PTEN, AKT2 | POLB 3958/4885MAPT 4510/4885KMT2A 3165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.