Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.40 |
| ▸ | GLP1R | P43220 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25755836 | 0.92 | EPHX2 (0.45) | EPHX2SMN1; SMN2FAAHGAATSHR | |
| SCHEMBL30180923 | 0.91 | EPHX2 (0.50) | EPHX2SMN1; SMN2FAAHGAAENPP2 | |
| SCHEMBL24514705 | 0.89 | EPHX2 (0.51) | EPHX2SMN1; SMN2FAAHENPP2LPAR1 | |
| SCHEMBL25884900 | 0.88 | FAAH (0.56) | FAAHENPP2LPAR1LPAR2DNM1 | |
| SCHEMBL26257840 | 0.88 | FAAH (0.56) | FAAHENPP2LPAR1LPAR2DNM1 | |
| SCHEMBL25480479 | 0.86 | TSHR (0.57) | EPHX2SMN1; SMN2FAAHGAAENPP2 | |
| SCHEMBL25110395 | 0.86 | TSHR (0.57) | EPHX2SMN1; SMN2FAAHGAAENPP2 | |
| SCHEMBL22793818 | 0.86 | TSHR (0.57) | EPHX2SMN1; SMN2FAAHGAAENPP2 | |
| SCHEMBL25110164 | 0.86 | TSHR (0.57) | EPHX2SMN1; SMN2FAAHGAAENPP2 | |
| SCHEMBL26740253 | 0.86 | GAA (0.49) | EPHX2SMN1; SMN2FAAHGAADNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251971-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |